Junjie Chen

Analysis of Combinatorial Knockout CRISPR screens with GRAPE: Genetic interaction Regression Analysis of Pairwise Effects

GRAPE identifies genetic interactions from combinatorial CRISPR screens with higher precision and recall than existing methods, revealing additional high-confidence interactions in published datasets.

Soluble E-cadherin Drives Brain Metastasis in Inflammatory Breast Cancer

This study identifies soluble E-cadherin as a driver of brain metastasis in inflammatory breast cancer, showing it promotes tumor survival and metastasis through XIAP-NF-kB activation and reactive astrocytosis.

HSP90 buffers deleterious genetic variations in BRCA1

This study shows HSP90 buffers BRCA1 mutations, reducing their clinical severity and contributing to PARP inhibitor resistance in cancer cells.

Optimal methods for analyzing targeted pairwise knockout screens

The paper compares methods for identifying synthetic lethal interactions from CRISPR screens and finds ZdLFC provides more consistent results across cell lines.

Comprehensive analysis of the host-virus interactome of SARS-CoV-2

The paper identifies 437 human proteins interacting with SARS-CoV-2 and compares interactomes of NSP1 and N protein with related coronaviruses to reveal common and divergent host pathways.