Savitri Krishnamurthy

Tumor emboli-associated adaptive stress response signatures identify aggressive disease features in inflammatory breast cancer

This study identifies adaptive stress response (ASR) signatures in inflammatory breast cancer (IBC) that correlate with tumor emboli survival, dissemination, and therapeutic response.

Soluble E-cadherin Drives Brain Metastasis in Inflammatory Breast Cancer

This study identifies soluble E-cadherin as a driver of brain metastasis in inflammatory breast cancer, showing it promotes tumor survival and metastasis through XIAP-NF-kB activation and reactive astrocytosis.

TGIRT-seq of Inflammatory Breast Cancer Tumor and Blood Samples Reveals Widespread Enhanced Transcription Impacting RNA splicing and Intronic RNAs in Plasma

This study uses TGIRT-seq to analyze IBC tumor and blood samples, revealing widespread transcriptional changes and RNA splicing impacts in plasma.

Spatial charting of single cell transcriptomes in tissues

This paper introduces CellTrek, a computational method that integrates scRNA-seq and spatial transcriptomics data to map single cells in tissues, showing accurate spatial organization in mouse and human tissues.