Senescence-Linked Fibrosis in the Aging Human Ovary Revealed by p16-Based Histological Profiling and Spatial Transcriptomics
Mark A. Watson, Pooja Raj Devrukhkar, Natalia Murad, Fan Wu, Moo Joong Kim, Hannah Anvari, Uyen Tran, Nicholas G. Martin, Tommy Tran, Giuliana Zaza, Kevin Schneider, Bikem Soygur, Elisheva D. Shanes, Denis Wirtz, Mary Ellen Pavone, , Birgit Schilling
The paper identifies and maps senescent cells in postmenopausal ovaries using p16 expression and spatial transcriptomics, revealing a fibro-inflammatory signature associated with aging.
bioRxiv · Dec 8, 2025 · PreprintCell Biology