Bikem Soygur

The human ovary exhibits dynamic molecular remodeling in the decades post-menopause

This study identifies age-related molecular changes in postmenopausal ovaries using proteomics, revealing dynamic remodeling and new biological insights.

Single-nucleus profiling reveals age-associated remodeling opposed by parity in the postmenopausal human ovary

The paper uses single-nucleus profiling to show age-related changes in the postmenopausal ovary, which are counteracted by parity.

Proteogenomic Profiling Reveals a Distinct Endogenous p16INK4a-Associated Senescence Signature in the Human Ovary.

The paper identifies a distinct p16INK4a-associated senescence signature in human ovarian tissue through proteogenomic profiling and spatial analysis.

Senescence-Linked Fibrosis in the Aging Human Ovary Revealed by p16-Based Histological Profiling and Spatial Transcriptomics

The paper identifies and maps senescent cells in postmenopausal ovaries using p16 expression and spatial transcriptomics, revealing a fibro-inflammatory signature associated with aging.

Comparative analysis of human and mouse ovaries across age

This study compares human and mouse ovarian biology across age using 3D-imaging, single-cell transcriptomics, and functional studies, identifying species-specific and age-related changes in follicle dynamics and gene expression.

A comprehensive multi-omics signature of doxorubicin-induced cellular senescence in the postmenopausal human ovary.

The paper establishes a senotype of doxorubicin-induced senescence in postmenopausal human ovarian tissue using single nuclei sequencing and proteomics.

Sustained fertility from first-wave follicle oocytes that pause their growth

The paper shows that some oocytes from the first juvenile wave pause growth and later resume, contributing to fertility beyond puberty.

CD38 regulates ovarian function and fecundity via NAD+ metabolism

This study shows CD38 loss increases ovarian NAD+ levels and fecundity in young mice but not in older mice.

Evidence for intercellular bridges and radial patterning of meiotic initiation in the human fetal ovary

This study uses 3D analysis to show radial meiotic initiation and intercellular bridges in human fetal ovaries, with variation in meiotic cell numbers and asynchronous transitions between mitotic and meiotic stages.

Apoptosis in the fetal testis eliminates developmentally defective germ cell clones

The paper shows that apoptosis in the fetal mouse testis removes developmentally defective germ cell clones based on intrinsic properties and epigenetic states.