This study identifies age-related molecular changes in postmenopausal ovaries using proteomics, revealing dynamic remodeling and new biological insights.

Aging Cell · Oct 1, 2026Peer-reviewedBiochemistry

Proteogenomic Profiling Reveals a Distinct Endogenous p16INK4a-Associated Senescence Signature in the Human Ovary.

Fiona Senchyna, Kevin Schneider, Pooja Raj Devrukhkar, Nicolas Martin, Tommy Tran, Josef Byrne, Mark A. Watson, Fei Wu, Minja Belić, Matías Fuentealba, Elisheva D. Shanes, Mary Ellen Pavone, Bikem Soygur, Birgit Schilling, Simon Melov, , David Furman

The paper identifies a distinct p16INK4a-associated senescence signature in human ovarian tissue through proteogenomic profiling and spatial analysis.

bioRxiv · Feb 4, 2026 · PreprintCell Biology

Senescence-Linked Fibrosis in the Aging Human Ovary Revealed by p16-Based Histological Profiling and Spatial Transcriptomics

Mark A. Watson, Pooja Raj Devrukhkar, Natalia Murad, Fan Wu, Moo Joong Kim, Hannah Anvari, Uyen Tran, Nicholas G. Martin, Tommy Tran, Giuliana Zaza, Kevin Schneider, Bikem Soygur, Elisheva D. Shanes, Denis Wirtz, Mary Ellen Pavone, , Birgit Schilling

The paper identifies and maps senescent cells in postmenopausal ovaries using p16 expression and spatial transcriptomics, revealing a fibro-inflammatory signature associated with aging.

bioRxiv · Dec 8, 2025 · PreprintCell Biology

A comprehensive multi-omics signature of doxorubicin-induced cellular senescence in the postmenopausal human ovary.

Pooja Raj Devrukhkar, Mark A. Watson, Bikem Soygur, Fei Wu, Joanna Bons, Hannah Anvari, Tomiris Atazhanova, Nicolas Martin, Tommy Tran, Kevin Schneider, Jacob Rose, Daniel A. Winer, Elisheva D. Shanes, Mary Ellen Pavone, Judith Campisi, , Francesca E. Duncan

The paper establishes a senotype of doxorubicin-induced senescence in postmenopausal human ovarian tissue using single nuclei sequencing and proteomics.

Aging Cell · Jun 1, 2025Peer-reviewedMolecular Biology