Head and Neck Cancer-derived small extracellular vesicles sensitize TRPV1+ neurons to mediate cancer pain
Kufreobong E. Inyang, Christine M. Evans, Matthew Heussner, Margaret Greene Petroff, Mark Reimers, Paola Drapkin Vermeer, Nathan Roger Tykocki, Joseph K. Folger, Geoffroy O. Laumet
This study identifies Cancer-sEVs as mediators of cancer pain by inducing neuronal hypersensitivity and translation, with potential therapeutic targets identified.
Pain · Sep 7, 2023Peer-reviewedNeuroscience