Adeno-Associated Virus (AAV) Synthetic Inverted Terminal Repeats Enhance Tissue-Specific Transduction and Alter the Vector Induced Stress Response
Tomoko Hasegawa, Naveen Vridhachalam, Ethan Sud Nikolai, Thanu Kalikiri, Mark Ross, Robert Toennisson, Priscila Villanueva, Alicia M Chandler, Liujiang Song, Jacquelyn J. Bower, R.Jude Samulski, Matthew Louis Hirsch
This study shows that synthetic AAV inverted terminal repeats improve tissue-specific transduction and reduce cellular stress response in multiple tissues.
bioRxiv · Jul 13, 2026 · PreprintMolecular Biology