Author

Margaret Caroline Stapleton

University of Pittsburgh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2 Bioengineering· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Assay:imaging· 3 Research Focus:differential expression· 2 Research Focus:spatial domain detection· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Yijen Lin WuiD· 4 shared Anthony ChristodoulouiD· 3 shared Cecilia Wen-Ya LoiD· 3 shared Devin Raine Everaldo CortesiD· 3 shared Cody Ruck· 2 shared Dalton West· 2 shared Eric S. GoetzmaniD· 2 shared Kristina Elsa Schwab· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersDevelopmental Biology

Yijen Lin WuORCID

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Author profile →

4 papers

Recent·Most cited

In Vivo 4D Oxy-Wavelet MRI as a Non-Invasive Biomarker of Brain Mitochondrial Function across the Lifespan

Devin Raine Everaldo Cortes, Sean Hartwick, Thomas Becker-Szurszewski, Kristina Elsa Schwab, Cody Ruck, Shanim Manzoor, Noah William Coulson, Dalton West, Margaret Caroline Stapleton, S. E. WYMAN, Cecilia Wen-Ya Lo, Sivakama Bharathi, Eric S. Goetzman, Anthony Christodoulou, Yijen Lin Wu

This paper introduces 4D Oxy-wavelet MRI to non-invasively assess mitochondrial function in living brains across the lifespan, validated in mouse models and with human feasibility data.

bioRxiv · May 23, 2026 · PreprintBioengineering

Mitotic Block and Epigenetic Repression Underlie Neurodevelopmental Defects and Neurobehavioral Deficits in Congenital Heart Disease

George C. Gabriel, Hisato Yagi, Tuantuan Tan, Abha Singh Bais, Benjamin J. Glennon, Margaret Caroline Stapleton, Lihua Huang, William T. Reynolds, Marla G. Shaffer, Madhavi K. Ganapathiraju, Dennis W. Simon, Ashok Panigrahy, Yijen Lin Wu, Cecilia W. Y. Lo

This study identifies mitotic block and epigenetic repression as causes of neurodevelopmental defects and neurobehavioral deficits in congenital heart disease using mouse models.

Nature Communications · Jan 7, 2025Peer-reviewedDevelopmental Biology

Modeling Normal Mouse Uterine Contraction and Placental Perfusion with Non- invasive Longitudinal Dynamic Contrast Enhancement MRI

Devin Raine Everaldo Cortes, Margaret Caroline Stapleton, Kristina Elsa Schwab, Dalton West, Noah William Coulson, Mary Gemmel, Anthony Christodoulou, Robert W. Powers, Yijen Lin Wu

This paper develops a non-invasive DCE-MRI pipeline to model uterine contraction and placental perfusion dynamics in mice, revealing asymmetric placental contractile motion.

PLoS ONE · Jul 1, 2024Peer-reviewedSystems Biology

Mitigation of Fetal Irradiation Injury from Mid-Gestation Total Body Radiation with Mitochondrial-Targeted GS-Nitroxide JP4-039

Yijen Lin Wu, Anthony Christodoulou, Jan Hendrik Beumer, Lora Heather Rigatti, Renee Fisher, Mark Ross, Simon C. Watkins, Devin Raine Everaldo Cortes, Cody Ruck, Shanim Manzoor, Samuel K. Wyman, Margaret Caroline Stapleton, Eric S. Goetzman, Sivakama S. Bharathi, Peter Wipf, , Joel S. Greenberger

Maternal administration of mitochondrial-targeted JP4-039 mitigates fetal brain injury and preserves mitochondrial function after mid-gestation radiation exposure.

bioRxiv · Feb 13, 2024 · PreprintDevelopmental Biology