The Staphylococcus aureus serine protease-like protein B is a potent allergen in a murine asthma model
J.M. Fournier, Marques L. Schilling, Christopher Saade, Hannes Wolfgramm, Sonja Buchholz, Susanne Neumeister, Yves Laumonnier, Henry J. McSorley, Sabrina Schulze, Leif Steil, Manuela Gesell Salazar, Matthias Sendler, Silva Holtfreter, Uwe Völker, Murthy N. Darisipudi, Barbara M. Bröker
This study shows that S. aureus SplB induces asthma-like symptoms in mice, requiring proteolytic activity and adaptive immunity, suggesting a direct role of bacterial allergens in asthma.
Journal of Allergy and Clinical Immunology · Sep 1, 2026Peer-reviewedImmunology