Silva Holtfreter

A mouse-adapted Staphylococcus aureus strain enables lifelong neonatal colonization and elicits a Th17-dominated immune response

This study establishes a neonatal S. aureus colonization model in mice using a mouse-adapted strain, showing persistent colonization and a Th17-dominated immune response.

The Staphylococcus aureus serine protease-like protein B is a potent allergen in a murine asthma model

This study shows that S. aureus SplB induces asthma-like symptoms in mice, requiring proteolytic activity and adaptive immunity, suggesting a direct role of bacterial allergens in asthma.

Immunoglobulin sub-class levels define inter-donor plasma variability: a longitudinal dual-lab study

This study identifies immunoglobulin sub-class levels as key factors in inter-donor plasma variability using longitudinal proteomic data from two labs.

E3 ubiquitin ligase SKP2 limits autophagy during S. aureus infection

This study shows that SKP2 limits autophagy during S. aureus infection by stabilizing and translocating to the cytoplasm, reducing LC3-II levels and intracellular bacterial survival.

Spontaneous preputial gland infection in Staphylococcus aureus-colonized male C57BL/6 mice triggers a Th17-driven immune response

This study shows that S. aureus colonization in male mice leads to spontaneous preputial gland infections driven by a Th17 immune response that fails to clear the bacteria.

Integrated genomic and proteomic analysis of the mouse-adapted Staphylococcus aureus strain JSNZ

The paper characterizes a mouse-adapted Staphylococcus aureus strain JSNZ through genomic and proteomic analysis, identifying it as a valuable reference strain for infection research.