Manuela Gesell Salazar

The Staphylococcus aureus serine protease-like protein B is a potent allergen in a murine asthma model

This study shows that S. aureus SplB induces asthma-like symptoms in mice, requiring proteolytic activity and adaptive immunity, suggesting a direct role of bacterial allergens in asthma.

Immunoglobulin sub-class levels define inter-donor plasma variability: a longitudinal dual-lab study

This study identifies immunoglobulin sub-class levels as key factors in inter-donor plasma variability using longitudinal proteomic data from two labs.

Unraveling proteomic chaos by independent component analysis - ClpX proficiency promotes the iron and oxygen limitation responses of Staphylococcus aureus and affects the intracellular bacterial behavior

This study uses proteomics and independent component analysis to show ClpX regulates S. aureus responses to iron and oxygen limitation and affects bacterial fitness and virulence.

Requirement of ClpX for CtsR dissociation from its operator elements upon heat stress in Bacillus subtilis

This study shows that ClpX is required for CtsR dissociation from its operator elements during heat stress in Bacillus subtilis, highlighting its role in activating the stress response regulon.

The global proteome of Streptococcus pneumoniae EF3030 under nutrient-defined in vitro conditions

This study optimizes a nutrient-defined medium for Streptococcus pneumoniae and uses it to analyze the global proteome during growth phase transitions, identifying proteins with altered abundance in late log phase.

Temperature-dependent regulation of bacterial cell division hydrolases by the coordinated action of a regulatory RNA and the ClpXP protease

This study identifies a temperature-sensitive regulatory mechanism in Staphylococcus aureus involving an RNA and ClpXP protease that controls cell division hydrolases.

Integrated genomic and proteomic analysis of the mouse-adapted Staphylococcus aureus strain JSNZ

The paper characterizes a mouse-adapted Staphylococcus aureus strain JSNZ through genomic and proteomic analysis, identifying it as a valuable reference strain for infection research.