Metabolic immunity to infection is driven by mitochondrial one-carbon metabolism
Tania Medeiros, Silvia Reato, Xianhe Li, Bruna Martins Garcia, Irina Rais, Kira Allmeroth, Matías Daniel Hartman, Martin Sebastian Denzel, Martin Purrio, Andrea Mesaros, Kit‐Yi Leung, Nicholas D. E. Greene, Patrick Giavalisco, Lena F. Pernas
The paper shows ATF4 rewires mitochondrial one-carbon metabolism during infection to restrict Toxoplasma growth via folate competition.
bioRxiv · May 7, 2025 · PreprintCell Biology