Induced Estrogen Receptor SUMOylation drives SERD activity
Matthias Hinterndorfer, Caroline Schätz, S. Schmitt, Martin Schoenlein, David M. Hoi, Izabela Kręcioch, Fabian Frommelt, Mykhailyna Shlei, Lukas Kater, Martin Pačesa, Miquel Muñoz i Ordoño, Georg Kempf, Katharina Kladnik, Paul Batty, Hana Imrichová, , Georg E. Winter
This study shows that SERDs induce ER SUMOylation, which recruits co-repressors to suppress transcription, rather than relying on ER degradation for their activity.
bioRxiv · Jun 26, 2026 · PreprintCancer Biology