Cryo-EM structure of human LRRC15 reveals the basis of therapeutic antibody recognition
Xiaomin Wang, Mihin Perera, Maryam Sana, Chunxiao Wang, Ching‐Seng Ang, Hariprasad Venugopal, Phillip Pymm, Wai‐Hong Tham, Jeffrey J. Babon, Andrew P. Leis, Rhys Grinter, Shabih Shakeel
The paper determines the cryo-EM structure of LRRC15 and identifies the epitope recognized by the antibody samrotamab, revealing a binding mode that preserves signaling surfaces.
bioRxiv · Jun 18, 2026 · PreprintBiochemistry