Phillip Pymm

The paper identifies nanobodies against PvAMA1 that inhibit Plasmodium vivax and falciparum invasion by binding novel epitopes distinct from known antibodies.

This study identifies nanobodies that target Plasmodium adhesins, blocking receptor engagement and inhibiting parasite invasion of red blood cells.

The paper determines the cryo-EM structure of LRRC15 and identifies the epitope recognized by the antibody samrotamab, revealing a binding mode that preserves signaling surfaces.

alpseq is an open-source pipeline for processing NGS data from nanobody libraries, enabling efficient analysis and identification of enriched sequences.

The paper identifies nanobodies targeting domain 3 of PfHAP2 and determines its crystal structure, providing structural insights for transmission-blocking interventions against malaria.

A chimeric coronavirus spike vaccine combining SARS-CoV-2 RBD and HKU-1 scaffold domains elicits potent neutralising antibodies and CD4 T cell help in mice and macaques.

The paper builds a machine learning model to predict KIR3DL1 binding to HLA class I allotypes, showing that binding is influenced by multiple non-additive regions beyond the classical Bw4 motif.