TMPRSS2 reduces antibody recognition of SARS-CoV-2 spike
Andréa Cottignies-Calamarte, Alejandro De Cruz, Cyril Planchais, Françoise Porrot, Mateo Kryzpow, Martin Jungbauer-Groznica, Eva Thuillier, Amelie Wileveau, Isabelle Staropoli, Florence Guivel‐Benhassine, Pierre Rosenbaum, I. Fernández, Felix Augusto Rey, Julian Buchrieser, Sophie Trouillet‐Assant, , Timothée Bruel
This study shows TMPRSS2 reduces antibody binding to SARS-CoV-2 spike by altering its structure and shedding, but not virion infectivity.
bioRxiv · Feb 25, 2026 · PreprintImmunology