This study examines how SARS-CoV-2 RBD antibodies differ in function, showing that neutralizing antibodies lose effectiveness against variants but retain effector functions, while non-neutralizers remain broadly reactive but less effective overall.

iScience · Sep 1, 2026Peer-reviewedImmunology

Temperature-Dependent Replication and Sensitivity to Innate Immunity of Human Coronavirus HKU1

Julian Buchrieser, Eva Thuillier, Jeanne Postal, Amelie Wileveau, Florence Guivel‐Benhassine, Isabelle Staropoli, Nell Saunders, Delphine Planas, Jamie A. Sugrue, Vincent Bondet, Ignacio Fernández, François Bontems, Françoise Porrot, Chloé Petiot, Matthieu Prot, , Olivier Schwartz

This study shows human coronavirus HKU1 replicates more efficiently at nasal temperature (33°C) than at body temperature (37°C), with differences in innate immune response and viral stability.

Nature Communications · Jul 27, 2026Peer-reviewedMicrobiology

TMPRSS2 reduces antibody recognition of SARS-CoV-2 spike

Andréa Cottignies-Calamarte, Alejandro De Cruz, Cyril Planchais, Françoise Porrot, Mateo Kryzpow, Martin Jungbauer-Groznica, Eva Thuillier, Amelie Wileveau, Isabelle Staropoli, Florence Guivel‐Benhassine, Pierre Rosenbaum, I. Fernández, Felix Augusto Rey, Julian Buchrieser, Sophie Trouillet‐Assant, , Timothée Bruel

This study shows TMPRSS2 reduces antibody binding to SARS-CoV-2 spike by altering its structure and shedding, but not virion infectivity.

bioRxiv · Feb 25, 2026 · PreprintImmunology