Felix Augusto Rey

Temperature-Dependent Replication and Sensitivity to Innate Immunity of Human Coronavirus HKU1

This study shows human coronavirus HKU1 replicates more efficiently at nasal temperature (33°C) than at body temperature (37°C), with differences in innate immune response and viral stability.

Variant-specific spike conformational dynamics shape memory B cell selection during recall

The paper shows that variant-specific spike conformational dynamics influence memory B cell recruitment and antibody responses during vaccination.

Monoclonal antibodies targeting the rabies virus glycoprotein promotes viral clearance and Fc-dependent neuroprotection in the infected brain

This study evaluates monoclonal antibodies RVC20 and RVC58 for treating symptomatic rabies in mice, showing that intravenous and intramuscular administration can clear viral infection and improve survival, with RVC58 achieving 80% survival.

TMPRSS2 reduces antibody recognition of SARS-CoV-2 spike

This study shows TMPRSS2 reduces antibody binding to SARS-CoV-2 spike by altering its structure and shedding, but not virion infectivity.

Dipeptidase 1 is a functional receptor for coronavirus PHEV

This study identifies dipeptidase 1 as the receptor for PHEV, showing it does not require sialic acid and reveals structural versatility in receptor binding.

Modulation of SARS-CoV-2 spike binding to ACE2 throughconformational selection

This study uses single-molecule techniques to show that SARS-CoV-2 spike protein RBD dynamics modulate ACE2 binding through conformational selection without affecting unbinding.

Molecular determinants of species-specific cell-cell recognition activating the class II gamete fusogen HAP2

The paper identifies molecular interactions between MAR1 and FUS1 that activate the HAP2 fusogen in Chlamydomonas gametes, revealing how species-specific adhesion initiates gamete fusion.

Intranasal delivery of a broadly neutralizing single domain antibody targeting ACE2 protects against SARS-CoV-2 infection

This paper develops a single domain antibody targeting ACE2 that protects against SARS-CoV-2 infection in mice when delivered intranasally.

Structures of the Foamy virus fusion protein reveal an unexpected link with the F protein of paramyxo- and pneumoviruses

The paper reports cryo-EM structures of foamy virus Env in pre- and post-fusion states, revealing structural similarity to paramyxovirus F proteins and suggesting an evolutionary link.

Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus

This study determines the structure of HKU1-CoV receptor binding domain in complex with TMPRSS2, identifying key residues for host tropism and revealing the structural basis of TMPRSS2 activation.

On the Role of VP3-PI3P Interaction in Birnavirus Endosomal Membrane Targeting

This paper investigates how VP3 protein of birnaviruses targets endosomal membranes via PI3P binding, revealing a two-stage mechanism critical for viral replication.

Hybrid sequence-structure based HMM models leverage theidentification of homologous proteins: the example of class II fusion

The paper introduces a hybrid sequence-structure HMM method to identify homologous proteins with low sequence identity and structural conservation, demonstrating its effectiveness in detecting class II fusion proteins.