Author

Pierre Rosenbaum

Institut PasteurORCID 0000-0001-9287-8985Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:virus· 1

Frequent Co-Authors

Cyril PlanchaisiD· 3 shared Hugo MouquetiD· 3 shared Florence Guivel‐BenhassineiD· 2 shared Isabelle StaropoliiD· 2 shared Olivier SchwartziD· 2 shared Timothée BrueliD· 2 shared Alejandro De CruziD· 1 shared Amelie WileveauiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersImmunology

Cyril PlanchaisORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Epitope-Driven Polyfunctional Divergence of SARS-CoV-2 RBD Antibodies

Pierre Rosenbaum, Cyril Planchais, Timothée Bruel, Maxime Beretta, Isabelle Staropoli, William Bolland, Florence Guivel‐Benhassine, Delphine Planas, French COVID Cohort Study Group, CORSER Study Group, Olivier Schwartz, Hugo Mouquet

This study examines how SARS-CoV-2 RBD antibodies differ in function, showing that neutralizing antibodies lose effectiveness against variants but retain effector functions, while non-neutralizers remain broadly reactive but less effective overall.

iScience · Sep 1, 2026Peer-reviewedImmunology

Evaluating SARS-CoV-2 Antibody Resilience via Prediction and Design of Escape Viral Variants

Marian Huot, Pierre Rosenbaum, Cyril Planchais, Hugo Mouquet, Rémi Monasson, Simona Cocco

This paper presents EscapeMap, a framework for predicting and designing SARS-CoV-2 variants that escape antibodies, and identifies antibody combinations less prone to simultaneous escape.

Cell Systems · Jul 17, 2026Peer-reviewedBioinformatics

TMPRSS2 reduces antibody recognition of SARS-CoV-2 spike

Andréa Cottignies-Calamarte, Alejandro De Cruz, Cyril Planchais, Françoise Porrot, Mateo Kryzpow, Martin Jungbauer-Groznica, Eva Thuillier, Amelie Wileveau, Isabelle Staropoli, Florence Guivel‐Benhassine, Pierre Rosenbaum, I. Fernández, Felix Augusto Rey, Julian Buchrieser, Sophie Trouillet‐Assant, , Timothée Bruel

This study shows TMPRSS2 reduces antibody binding to SARS-CoV-2 spike by altering its structure and shedding, but not virion infectivity.

bioRxiv · Feb 25, 2026 · PreprintImmunology