Cyril Planchais

Epitope-Driven Polyfunctional Divergence of SARS-CoV-2 RBD Antibodies

This study examines how SARS-CoV-2 RBD antibodies differ in function, showing that neutralizing antibodies lose effectiveness against variants but retain effector functions, while non-neutralizers remain broadly reactive but less effective overall.

Variant-specific spike conformational dynamics shape memory B cell selection during recall

The paper shows that variant-specific spike conformational dynamics influence memory B cell recruitment and antibody responses during vaccination.

Evaluating SARS-CoV-2 Antibody Resilience via Prediction and Design of Escape Viral Variants

This paper presents EscapeMap, a framework for predicting and designing SARS-CoV-2 variants that escape antibodies, and identifies antibody combinations less prone to simultaneous escape.

TMPRSS2 reduces antibody recognition of SARS-CoV-2 spike

This study shows TMPRSS2 reduces antibody binding to SARS-CoV-2 spike by altering its structure and shedding, but not virion infectivity.

Optimized pipeline for generating highly potent neutralizing Affitins: application to SARS-CoV-2 spike protein

The paper develops a pipeline to generate potent Affitins targeting SARS-CoV-2 spike protein RBD, achieving high neutralization potency with IC50 values as low as 0.8 pM.

Escape of SARS-CoV-2 variants KP1.1, LB.1 and KP3.3 from approved monoclonal antibodies

The paper evaluates the neutralization activity of two new monoclonal antibodies against emerging SARS-CoV-2 variants and finds reduced efficacy against some sublineages.