A mutational gradient drives somatic mutation accumulation in mitochondrial DNA and influences germline polymorphisms and genome composition
Mónica Sánchez-Contreras, Mariya T. Sweetwyne, Brendan F. Kohrn, Kristine A. Tsantilas, Michael J. Hipp, Elizabeth K. Schmidt, Jeanne Fredrickson, Jeremy A Whitson, Matthew D Campbell, Peter S. Rabinovitch, David Joseph Marcinek, Scott R. Kennedy
The paper identifies a mutational gradient in mtDNA that correlates with replication and influences mutation accumulation and genome composition.
Nucleic Acids Research · Sep 22, 2021Peer-reviewedGenomics