Mónica Sánchez-Contreras

This study isolates podocyte mitochondria from mice to show they have higher respiratory capacity than tubule mitochondria, with age- and sex-dependent differences.

This study shows that reduced IGF-1 signaling extends lifespan in mammals but not in mitochondrial mutator mice, indicating that mitochondrial genome stability is essential for the longevity benefits of IGF-1 suppression.

The paper compares mitochondrial interactomes of podocytes and tubules in mouse kidney using quantitative cross-linking mass spectrometry, revealing distinct pathways and enzyme activities.

The paper detects age-related tissue-specific accumulation of mtDNA mutations in mice and shows oxidative damage mutations are reduced with treatment.

The paper identifies a mutational gradient in mtDNA that correlates with replication and influences mutation accumulation and genome composition.