Author

Matthew Kieffer

St. Jude Children's Research Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:experimental assay· 1 Assay:metabolomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Elizabeth S. StewartiD· 2 shared Michael A. DyeriD· 2 shared Yiping FaniD· 2 shared Alaa RefaatiD· 1 shared Anand G. PateliD· 1 shared Anang A. ShelatiD· 1 shared Ankhbayar Lkhagva· 1 shared Anthony A. HighiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Elizabeth S. StewartORCID

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2 papers

Recent·Most cited

SLFN11 Loss-Induced Chemoresistance is Associated with Overexpression of Glycerophospholipid Biosynthesis in Ewing Sarcoma.

Kasturee Chakraborty, Ritambhar Burman, Saharsh Satheesh, Matthew Kieffer, Chandni Karuhatty, Zuo‐Fei Yuan, Haiyan Tan, Ankhbayar Lkhagva, Anthony A. High, Xusheng Wang, Alaa Refaat, Weixing Zhang, Yaxu Wang, Yiping Fan, M. Madan Babu, , Puneet Bagga

The paper identifies glycerophospholipid biosynthesis upregulation as a mechanism of chemoresistance in SLFN11-loss Ewing sarcoma and shows that inhibiting this pathway enhances DNA-damaging agent efficacy.

bioRxiv · May 9, 2025 · PreprintCancer Biology

Preclinical Pediatric Molecular Analysis for Therapy Choice (MATCH)

Kaley Blankenship, Ti‐Cheng Chang, Yiping Fan, Brittney Gordon, William C. Wright, Matthew Kieffer, Åsa Karlström, Jongrye Jeon, Anand G. Patel, Jason D. Dapper, William V. Caufield, Burgess B. Freeman, Sara Michele Federico, Michael R. Clay, G. G. Wu, , Elizabeth S. Stewart

This paper establishes a diverse collection of preclinical models for pediatric solid tumors and demonstrates their utility in precision medicine trials and drug testing.

bioRxiv · Jul 22, 2024 · PreprintCancer Biology