Astrocytic CREB regulates transcriptional, neuronal, and behavioral responses to cocaine
Leanne Melissa Holt, Angelica M. Minier-Toribio, Rita Futamura, Caleb J. Browne, Freddyson J. Martínez-Rivera, Tamara Markovic, Trevonn M. Gyles, Szu-Ying Yeh, Eric M. Parise, Matthew Rivera, Corrine H. Azizian, Yun Young Yim, Veronika Kondev, Molly S. Estill, Shi Fang Yan, , Eric J. Nestler
The paper investigates cocaine-induced astrocyte-specific transcriptome in mice, identifies CREB as a key regulator, and shows its role in modulating neuronal and behavioral responses to cocaine.
bioRxiv · Jun 4, 2025 · PreprintNeuroscience