Eric M. Parise

The paper develops a method to study endogenous protein complexes in brain tissue and finds mGluR2/3 heterodimers are abundant in specific human brain regions and associated with depression.

This study identifies transcriptional differences in mice with antidepressant resistance using RNA sequencing of brain regions after stress and drug treatment.

The paper identifies a shared transcriptional network in the nucleus accumbens that supports stress resilience in both sexes and shows causal effects of hub genes.

The paper investigates cocaine-induced astrocyte-specific transcriptome in mice, identifies CREB as a key regulator, and shows its role in modulating neuronal and behavioral responses to cocaine.

This study identifies D1 and D2 dopamine receptor-expressing neurons in the mouse ventral hippocampus and shows they mediate opposing approach/avoidance behaviors during anxiety-related tasks.

This study identifies H3K27me1 as a chromatin scar that mediates lifelong stress susceptibility through its role in altering gene expression in the nucleus accumbens.

The paper identifies sex-specific regulation of stress susceptibility by the astrocytic gene Htra1 in mice and humans, showing differential effects on neuronal signaling and ECM integrity.

This study shows that astrocytic CREB in the nucleus accumbens influences susceptibility to chronic stress through transcriptional changes.

This study identifies sex-specific gene modules linked to MDD symptom domains in brain regions, revealing distinct transcriptional signatures in males and females.

This study shows that manipulating ERK2 levels in the nucleus accumbens of rats alters behaviors related to reward and aversion, with overexpression increasing depression-like and cocaine sensitivity behaviors, and knockdown reducing them.

This study identifies transcriptional changes in the brain reward circuit across heroin exposure and seeking behaviors in mice, revealing molecular mechanisms and potential therapeutic targets for opioid use disorder.

The paper shows that adolescent social isolation causes sex-specific changes in the medial amygdala's transcriptome and behavior, with Crym playing a key role in these effects.

This study shows that miR-218 in the medial prefrontal cortex (mPFC) influences resilience or susceptibility to depression-like behaviors in mice and that its expression in blood correlates with mPFC levels.

The paper identifies Zfp189 as a key driver of a transcriptional network promoting stress resilience in prefrontal cortex neurons through CREB regulation.

The paper identifies a spatiotemporal dynamic network in the brain associated with depression vulnerability using machine learning and LFP data from stressed mice.