Trevonn M. Gyles

Transcriptional Profiles of Antidepressant Resistance Across the Corticolimbic Pathway of Chronically Stressed Mice

This study identifies transcriptional differences in mice with antidepressant resistance using RNA sequencing of brain regions after stress and drug treatment.

A shared transcriptional network in the nucleus accumbens supports resilience to chronic stress across sex.

The paper identifies a shared transcriptional network in the nucleus accumbens that supports stress resilience in both sexes and shows causal effects of hub genes.

Cortical astrocytes control stress resilience

The paper identifies a role for prefrontal cortex astrocytes in stress resilience using mouse models and RNA-sequencing, showing distinct transcriptional responses between resilient and susceptible mice.

Astrocytic CREB regulates transcriptional, neuronal, and behavioral responses to cocaine

The paper investigates cocaine-induced astrocyte-specific transcriptome in mice, identifies CREB as a key regulator, and shows its role in modulating neuronal and behavioral responses to cocaine.

A meta-analysis of the effects of early life stress on the prefrontal cortex transcriptome suggests long-term effects on myelin

This paper performs a meta-analysis of gene expression data from five datasets to identify long-term effects of early life stress on the prefrontal cortex, finding consistent downregulation of myelin-related genes and upregulation of genes related to Major Depressive Disorder.

Sex-Specific Regulation of Stress Susceptibility by the Astrocytic Gene Htra1

The paper identifies sex-specific regulation of stress susceptibility by the astrocytic gene Htra1 in mice and humans, showing differential effects on neuronal signaling and ECM integrity.

Astrocytic CREB in nucleus accumbens promotes susceptibility to chronic stress

This study shows that astrocytic CREB in the nucleus accumbens influences susceptibility to chronic stress through transcriptional changes.

Colonization at birth with human CST IV cervicovaginal microbiota alters development and increases neonatal mortality in mice

The paper shows that colonization with nonoptimal human cervicovaginal microbiota in mice leads to developmental issues and increased neonatal mortality.