Leanne Melissa Holt

The paper identifies a shared transcriptional network in the nucleus accumbens that supports stress resilience in both sexes and shows causal effects of hub genes.

The paper identifies a role for prefrontal cortex astrocytes in stress resilience using mouse models and RNA-sequencing, showing distinct transcriptional responses between resilient and susceptible mice.

The paper investigates cocaine-induced astrocyte-specific transcriptome in mice, identifies CREB as a key regulator, and shows its role in modulating neuronal and behavioral responses to cocaine.

This study shows that E2F3a overexpression in D1-MSNs increases cocaine reward in both male and female mice, while knockdown has opposite effects, with no impact in D2-MSNs.

The paper identifies sex-specific regulation of stress susceptibility by the astrocytic gene Htra1 in mice and humans, showing differential effects on neuronal signaling and ECM integrity.

The paper compares gene expression in the nucleus accumbens during cocaine withdrawal and extinction in rats, identifying distinct transcriptional patterns associated with different behavioral outcomes.

This study shows that astrocytic CREB in the nucleus accumbens influences susceptibility to chronic stress through transcriptional changes.

The paper identifies distinct transcriptional profiles in striatal ensembles activated during initial vs. repeated cocaine exposure, revealing differences in neuronal recruitment and memory retrieval mechanisms.

The paper examines transcriptomic changes in D1 and D2 medium spiny neurons of the nucleus accumbens after cocaine and morphine exposure, revealing shared and divergent regulatory patterns.

This study identifies RXR as a key regulator of drug reward sensitivity in the nucleus accumbens through transcriptional control of neuronal excitability in mice.

The paper investigates how CREB function in specific brain regions influences distinct forms of regret related to resilience and susceptibility to chronic stress in mice.

This study identifies BDNF/TrkB.T1 signaling as critical for astrocyte morphological maturation, showing increased complexity and synaptogenesis in its presence.