A Spike Trimer Dimer-Inducing Nanobody with Anti-Sarbecovirus Activity
Iris C. Swart, Oliver J. Debski-Antoniak, Aneta Zegar, Thijs de Bouter, Marianthi Chatziandreou, Max van den Berg, Ieva Drulyte, Krzysztof Pyrć, Cornelis A. M. de Haan, Daniel L. Hurdiss, Berend‐Jan Bosch, Sabrina Oliveira
This paper describes a nanobody, 7F, that neutralizes SARS-CoV-2 and cross-neutralizes SARS-CoV and SARS-like CoV pseudoviruses by inducing spike trimer dimers and shows therapeutic potential in 3D tissue cultures.
Journal of Nanobiotechnology · Mar 10, 2025Peer-reviewedMicrobiology