Author

Krzysztof Pyrć

Jagiellonian UniversityORCID 0000-0002-3867-7688Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:ecology & biodiversity· 1

Frequent Co-Authors

Étienne DecrolyiD· 2 shared Adrien DelpaliD· 1 shared Aleksandra MilewskaiD· 1 shared Alex MatsudaiD· 1 shared Alexander MyronoviD· 1 shared Aneta ZegariD· 1 shared Anna CzarnaiD· 1 shared Anna KulaiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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2 shared papersMicrobiology

Étienne DecrolyORCID

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Author profile →

5 papers

Recent·Most cited

A 10-year longitudinal study reveals bat-driven SARSr-CoV evolution

Daphné de Riols de Fonclare, Artur Szczepański, Aleksandra Milewska, Sandrine Corbet, Lucile Rouilly, Laure Diancourt, Baptiste Elie, Sébastian Lequime, Bryce Leterrier, Sébastien J. Puechmaille, Frédéric Touzalin, Étienne Decroly, Astrid Vabret, Sophie Le Poder, Krzysztof Pyrć, Meriadeg Ar Gouilh

This study tracks SARSr-CoV evolution in Rhinolophus bats over 10 years, revealing host factors driving viral diversification and adaptation.

bioRxiv · Oct 5, 2026 · PreprintMicrobiology

Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase

Irene Georgiou, Colin Robinson, Sean N. O’Byrne, Alex Matsuda, Przemysław Grygier, Craig D. L. Smith, Sandra O’Neill, Shamshad A. Ahmad, Suzanne Norval, John M. Post, G. J. Mirjam Groenewold, Nadya Urakova, Patrick Wanningen, Leanid Kresik, Jacek Plewka, , Ian Hugh Gilbert

The paper develops bi-substrate inhibitors of SARS-CoV-2 nsp14 methyltransferase using structure-guided design, achieving nanomolar potency but limited cellular antiviral activity.

RSC Medicinal Chemistry · Jan 1, 2026Peer-reviewedBiochemistry

A Spike Trimer Dimer-Inducing Nanobody with Anti-Sarbecovirus Activity

Iris C. Swart, Oliver J. Debski-Antoniak, Aneta Zegar, Thijs de Bouter, Marianthi Chatziandreou, Max van den Berg, Ieva Drulyte, Krzysztof Pyrć, Cornelis A. M. de Haan, Daniel L. Hurdiss, Berend‐Jan Bosch, Sabrina Oliveira

This paper describes a nanobody, 7F, that neutralizes SARS-CoV-2 and cross-neutralizes SARS-CoV and SARS-like CoV pseudoviruses by inducing spike trimer dimers and shows therapeutic potential in 3D tissue cultures.

Journal of Nanobiotechnology · Mar 10, 2025Peer-reviewedMicrobiology

Distinguishable topological properties of functional genome networks in HIV-1 reservoirs

Janusz Wisniewski, Kamil Więcek, Haider Ali, Krzysztof Pyrć, Anna Kula, Marek Wagner, Heng‐Chang Chen

This study uses graph theory to analyze topological properties of HIV-1 reservoir networks, revealing differences between elite controllers and ART-treated patients.

bioRxiv · Feb 5, 2024 · PreprintGenomics

AI aided design of epitope-based vaccine for the induction of cellular immune responses against SARS-CoV-2

Giovanni Mazzocco, Iga Niemiec, Alexander Myronov, Piotr Skoczylas, J. Kaczmarczyk, Anna Sanecka-Duin, Katarzyna Gruba, Paulina Król, Michał Drwal, Marian Szczepanik, Krzysztof Pyrć, Piotr Stępniak

This paper uses AI and bioinformatics to design epitope-based vaccines for cellular immunity against SARS-CoV-2, evaluating immunogenicity and safety risks.

Frontiers in Genetics · Mar 25, 2021Peer-reviewedBioinformatics