Domain-resolved epitope mapping of B7-H3-targeting VHH-Fcs defines isoform-selective binders for antibody-drug conjugate development
Xiang Fang, Benjamin Chalopin, S. Seyda Gokturk, Ankita S. Bhagwani, Milana Sudareva, Ronja Molkenbur, Wenjin Tian, Min Feng, Fenna L. H. van Rijt, Kim van Noort, Jannet Koelewijn, Marianthi Chatziandreou, Baojie Zhang, Johannes H. M. Merks, Claudia Rössig, , Claudia Y. Janda
The paper maps epitopes of B7-H3-targeting VHH-Fcs to identify isoform-selective binders for antibody-drug conjugate development.
bioRxiv · Oct 19, 2026 · PreprintCancer Biology