''Self-gapping'' by a C-terminal domain arginine finger regulates GTP hydrolysis in bacterial zinc metallochaperones
Joseph S. Rocchio, Maximillian K. Osterberg, Emma M. McRae, Nancy Jaiswal, Katherine A. Edmonds, D. Annie Doyle, Eric Patrick Skaar, David P. Giedroc
This paper identifies a 'self-gapping' mechanism in bacterial COG0523 metallochaperones where the C-terminal domain activates GTP hydrolysis via an arginine finger and lysine residue, revealing a novel regulatory mechanism.
bioRxiv · Mar 5, 2026 · PreprintBiochemistry