An Iron-regulated Signalling Pathway Controls Adipose Browning and Cancer Cachexia
Jung Seung Nam, Maya S. Dixon, Pardis Ahmadi, Kathrin Schilling, Samuel S. Pan, Yuxuan Chen, Nal Ae Yoon, Yanping Sun, Jordan Lu, Shu Ichimiya, Jeanine M. Genkinger, Thomas C. Caffrey, Kelsey A. Klute, Benjamin J. Swanson, Paul M. Grandgenett, , Iok In Christine Chio
This study identifies an iron-regulated signaling pathway involving MSRA and PKA that drives adipose browning and cancer cachexia, showing that MsrA deletion reduces cachexia in PDA models.
bioRxiv · Jul 16, 2025 · PreprintCancer Biology