This study identifies eIF4G2 as a translational checkpoint that restricts pancreatic cancer progression by maintaining epithelial identity and limiting metastasis.

Cancer Research · May 27, 2026Peer-reviewedCancer Biology

TMPO promotes cellular dissemination and metastasis in circulating tumor cells

Arianna Giacobbe, Aleksandar Obradović, Jinqiu Lu, Soonbum Park, Carlos Pedraz‐Valdunciel, Giuseppe Nicolò Fanelli, Aunika Zheng, Jaime Y. Kim, Maya Stella Dixon, Jung Seung Nam, Florencia Picech, Caroline J. Laplaca, Renu K. Virk, Matteo Di Bernardo, Alexander Chui, , Cory T. Abate-Shen

This study identifies TMPO as a driver of CTC heterogeneity and metastasis in prostate cancer by enhancing survival under metabolic stress.

bioRxiv · Dec 27, 2025 · PreprintCell Biology

Netrin-1 promotes pancreatic tumorigenesis and innervation through NEO1.

Yosuke Ochiai, Hiroki Kobayashi, Masaki Sunagawa, Taisuke Baba, Ermanno Malagola, Feijing Wu, Takayuki Tanaka, Masahiro Hata, Junya Arai, Zhengyu Jiang, Ruth Aroon White, Xiaofei Zhi, Jin Qian, Quin T. Waterbury, Ru‐Hong Tu, , Timothy Cragin Wang

This study identifies NTN1/NEO1 as a key driver of pancreatic tumorigenesis and metastasis by promoting cancer stemness, EMT, and nerve innervation.

bioRxiv · Jul 22, 2025 · PreprintCancer Biology

An Iron-regulated Signalling Pathway Controls Adipose Browning and Cancer Cachexia

Jung Seung Nam, Maya S. Dixon, Pardis Ahmadi, Kathrin Schilling, Samuel S. Pan, Yuxuan Chen, Nal Ae Yoon, Yanping Sun, Jordan Lu, Shu Ichimiya, Jeanine M. Genkinger, Thomas C. Caffrey, Kelsey A. Klute, Benjamin J. Swanson, Paul M. Grandgenett, , Iok In Christine Chio

This study identifies an iron-regulated signaling pathway involving MSRA and PKA that drives adipose browning and cancer cachexia, showing that MsrA deletion reduces cachexia in PDA models.

bioRxiv · Jul 16, 2025 · PreprintCancer Biology