Paul M. Grandgenett

An Integrated Preclinical Platform for Lethal Neuroendocrine Prostate Cancer from Rapid Autopsy Bone and Liver Metastases.

This paper establishes patient-derived models of neuroendocrine prostate cancer (NEPC) from metastases, showing they retain tumor heterogeneity and can model metastatic progression.

The circadian gene Dec2 promotes pancreatic cancer dormancy by regulating tumor cell antigen presentation to facilitate immune evasion

This study identifies Dec2 as a circadian gene that promotes pancreatic cancer dormancy by reducing MHC-I antigen presentation, enabling immune evasion.

AI-powered Deep Visual Proteomics reveals critical molecular transitions in pancreatic cancer precursors

This study uses AI-driven proteomics to identify molecular transitions in pancreatic cancer precursors, revealing early molecular changes in histologically normal tissue.

An Iron-regulated Signalling Pathway Controls Adipose Browning and Cancer Cachexia

This study identifies an iron-regulated signaling pathway involving MSRA and PKA that drives adipose browning and cancer cachexia, showing that MsrA deletion reduces cachexia in PDA models.

Pancreatic cancer cachexia is mediated by PTHrP-driven disruption of adipose de novo lipogenesis

This study identifies PTHrP as a driver of pancreatic cancer cachexia by suppressing adipose de novo lipogenesis, showing that blocking PTHrP-PTH1R signaling reduces wasting in mouse models.

radioGWAS: link radiome to genome to discover driver genes with somatic mutations for heterogeneous tumor image phenotype in pancreatic cancer

This study links radiomic features to genome-wide associations in pancreatic cancer to identify driver genes associated with tumor structural heterogeneity and patient survival.