Jose Antonio Gomez-Sanchez

The paper performs proteomic analysis of brain cell type-specific extracellular vesicles in mice, identifying distinct molecular signatures and highlighting the GlialCAM/MLC1 network in astrocytic EVs.

This study shows that inflammation-induced epigenetic memory in OPCs improves remyelination in aged mice by enhancing differentiation and reducing axonal damage.

This study identifies Plastin-3 membrane recruitment as a critical step driven by ROCK1 activation in the entosis process.

This study evaluates motoneuronal regeneration and Wallerian degeneration after sciatic nerve injury at different postnatal stages in mice, finding that regenerative capacity is linked to intrinsic growth state rather than age.

The paper identifies kranocytes as sensory platforms in neuromuscular junctions that connect adjacent junctions, interact with microvasculature, and respond to injury or disease.

This study introduces a novel laser-induced axotomy method in adult mice to study axonal degeneration and regeneration dynamics, revealing delayed degeneration in Sarm1-null mice.

The paper validates an MRI framework for detecting axonal damage in rats and humans, showing increased axonal caliber in both pathological and normal-appearing white matter in multiple sclerosis patients.

The paper shows SARM1 is present in oligodendrocytes but not Schwann cells, and its deletion does not affect myelination in zebrafish or mice.

This study shows that senescent Schwann cells, induced by aging and chronic denervation, impair axonal regeneration by reducing c-Jun expression and secreting inhibitory factors, and that eliminating these cells improves regeneration.

This paper identifies a functional switch in Fasciclin 2 that controls organ size in Drosophila by promoting growth autonomously and restraining it non-autonomously through EGFR interactions.

The paper shows that restoring Schwann cell c-Jun rescues nerve regeneration failures in aging and chronic denervation by enhancing regenerative support.