Bina Santoro

Activity-based profiling of primary brain cells identifies covalent allosteric modulators of HCN channels

Comprehensive classification of HCN1 variants linked to neurodevelopmental disorders with and without epilepsy

This study functionally classifies HCN1 variants in patients with neurodevelopmental disorders, finding genotype-phenotype correlations and potential therapeutic targets.

Chemogenetic activation of hippocampal area CA2 promotes acute and chronic seizures in a mouse model of epilepsy

This paper shows that chemogenetic activation of hippocampal CA2 neurons increases seizure frequency and duration in a mouse model of epilepsy.

Cell type-specific impact of aging and Alzheimer disease on hippocampal CA1 perforant path input

The paper examines how aging and Alzheimer disease affect perforant path input to hippocampal CA1 pyramidal neurons in mice, finding unique aging-related changes in excitatory responses.

Reduced cholecystokinin-expressing interneuron input contributes to disinhibition of the hippocampal CA2 region in a mouse model of temporal lobe epilepsy

The paper investigates inhibitory deficits in the hippocampal CA2 region of a mouse model of temporal lobe epilepsy, identifying reduced cholecystokinin-expressing interneurons and impaired inhibition.

The HCN1 hyperpolarization-activated cyclic nucleotide-gated channel enhances evoked GABA release from parvalbumin positive interneurons

This study investigates how HCN1 channels in parvalbumin-positive interneurons regulate GABA release in hippocampal CA1, showing that HCN1 enhances inhibitory transmission.

Seizures, behavioral deficits and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy

This study presents two genetic mouse models of HCN1 epileptic encephalopathy, showing seizure susceptibility and adverse drug responses, highlighting the need for tailored therapies.

Enhanced excitability of the hippocampal CA2 region and its contribution to seizure generation in a mouse model of temporal lobe epilepsy

This study investigates the role of hippocampal CA2 region in seizure generation in a mouse model of temporal lobe epilepsy, finding that enhanced excitability and reduced inhibition in CA2 contribute to seizure activity.