IL-17RC signaling connects intestinal microbiota and neuroimmune interactions in atherosclerosis
Aleksandra Mazitova, Jiani Zhu, Richard Rosario Rodrigues, Kaitlyn Nguyen, Meghan Terrell, Pavithra Nedumaran, Jacob T. Alltucker, Mingtian Che, Kelsey E. Jarrett, Kevin P. Downs, Christian Stehlik, Thomas Q. de Aguiar Vallim, Andrew V. Kossenkov, Bernd Schnabl, Simon Knott, , Ekaterina K. Koltsova
This study shows IL-17RC signaling in the intestine prevents atherosclerosis by controlling microbiota and perivascular innervation, with loss of IL-17RC increasing inflammation and disease.
bioRxiv · Mar 10, 2026 · PreprintImmunology