Aberrant expression of histone H2B variants reshape chromatin and alter oncogenic gene expression programs
Wesley N. Saintilnord, Youssef A. Hegazy, Kristin V Chesnutt, Meredith Eckstein, Richard N Cassidy, Héjer Dhahri, Richard Lynn Bennett, Daniël P. Melters, Élisson Nogueira Lopes, Zhen Fu, Kin H. Lau, Darrell P. Chandler, Michael Guy Poirier, Yamini Dalal, Jonathan D. Licht, Yvonne N. Fondufe‐Mittendorf
This study shows that H2B variants alter chromatin structure and oncogenic gene expression, suggesting they may be early cancer biomarkers and therapeutic targets.
bioRxiv · Nov 18, 2024 · PreprintCancer Biology