Author

Darrell P. Chandler

Van Andel InstitutePrimary ORCID profile (0000-0002-6462-0941 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Darrell P. ChandleriD2 papers · Van Andel Institute

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Daniël P. MeltersiD· 2 shared Élisson Nogueira LopesiD· 2 shared Héjer DhahriiD· 2 shared Jonathan D. LichtiD· 2 shared Kin H. LauiD· 2 shared Wesley N. SaintilnordiD· 2 shared Yamini DalaliD· 2 shared Youssef A. HegazyiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Daniël P. MeltersORCID

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2 papers

Recent·Most cited

Incorporating histone H2B variants into chromatin modifies chromatin accessibility to induce epithelial to mesenchymal transition in breast cancer

Héjer Dhahri, Kin H. Lau, Wesley N. Saintilnord, Élisson Nogueira Lopes, Hannah N. Damico, Youssef A. Hegazy, Flávio Romero Palma, Daniël P. Melters, Darrell P. Chandler, Yamini Dalal, Jonathan D. Licht, Marcelo Gialluisi Bonini, Yvonne N. Fondufe‐Mittendorf

This study shows that H2B variants, particularly H2B1O, alter chromatin accessibility and induce EMT in breast cancer, suggesting their role as onco-histones and potential therapeutic targets.

Oncogene · Jan 24, 2026Peer-reviewedBiochemistry

Aberrant expression of histone H2B variants reshape chromatin and alter oncogenic gene expression programs

Wesley N. Saintilnord, Youssef A. Hegazy, Kristin V Chesnutt, Meredith Eckstein, Richard N Cassidy, Héjer Dhahri, Richard Lynn Bennett, Daniël P. Melters, Élisson Nogueira Lopes, Zhen Fu, Kin H. Lau, Darrell P. Chandler, Michael Guy Poirier, Yamini Dalal, Jonathan D. Licht, Yvonne N. Fondufe‐Mittendorf

This study shows that H2B variants alter chromatin structure and oncogenic gene expression, suggesting they may be early cancer biomarkers and therapeutic targets.

bioRxiv · Nov 18, 2024 · PreprintCancer Biology