A reproducible human brain tissue model to study physiological and disease-associated microglia phenotypes
Julien Klimmt, Carolina Cardoso Gonçalves, Jessica Valentina Montgomery, Stephan A. Müller, Merle Bublitz, Severin Filser, Lars Paeger, Brigitte Nuscher, Angelika Dannert, Sigrun Roeber, Veronica M. Pravatà, Martina Schifferer, Joshua James Shrouder, Nathalie Schulz, Judit González-Gallego, , Dominik Paquet
This paper develops a 3D cortical brain tissue model with mature microglia that recapitulates Alzheimer's disease hallmarks and enables study of microglia phenotypes.
bioRxiv · Jan 21, 2026 · PreprintNeuroscience