Hypoxia-activated scleraxis a mediates epicardial progenitor differentiation into a unique cardiac perivascular cell type
Björn Perder, Yu Xia, Jun Yao, Ignace Van der Wee, Miaoyan Qiu, Alvin Gea Chen Yao, Muhammad Naeem, Paul Zumbo, Avi Yakubov, Stephanie L. Tsai, Kazu Kikuchi, Jenna Lauren Galloway, Doron Betel, Todd Evans, Michael R. M. Harrison, Jingli Cao
This study identifies Scleraxis a as a key regulator of epicardial progenitor differentiation into a unique cardiac perivascular cell type in zebrafish, revealing a hypoxia-responsive pathway involved in coronary vessel development.
Nature Communications · Aug 20, 2026Peer-reviewedDevelopmental Biology