Biophysical Basis of Paracellular Barrier Modulation by a Pan-Claudin-Binding Molecule
Chinemerem P. Ogbu, Mason de las Alas, Alexandria M. Mandriota, Xiangdong Liu, Srajan Kapoor, Jagrity Choudhury, Yasmeen N. Ruma, Michael Goodman, Charles R. Sanders, Tamir Gonen, Anthony A. Kossiakoff, Michael E. Duffey, Alex J. Vecchio
The paper develops a synthetic antibody fragment that binds to 10 claudin subtypes, opening tight junctions and modulating paracellular permeability.
PNAS Nexus · Jun 1, 2025Peer-reviewedBiophysics