Jagrity Choudhury

The biophysical interaction network that couples zona occludens-1 to membrane proteins at tight junctions

This study maps the biophysical interaction network of ZO-1 with tight junction transmembrane proteins, revealing how they couple intracellular and extracellular signaling through binding mechanisms and phase separation.

A conformationally heterogeneous bending pivot enables bent-to-straight transition in the central helix of mycobacterial FtsZ

This study uses multi-temperature crystallography and ensemble modeling to show that conformational heterogeneity in the bending pivot of mycobacterial FtsZ enables the bent-to-straight transition in its central helix.

Biophysical Basis of Paracellular Barrier Modulation by a Pan-Claudin-Binding Molecule

The paper develops a synthetic antibody fragment that binds to 10 claudin subtypes, opening tight junctions and modulating paracellular permeability.

Tubules, rods and spirals: diverse modes of SepF-FtsZ assembling

This study investigates the in vitro interactions between FtsZ and SepF from three bacteria, revealing different structural outcomes of SepF-FtsZ assembly.

BindCraft: one-shot design of functional protein binders

Hallucinating binders by backpropagating through AlphaFold2 weights gave, across 12 targets, binders in 10-100% of the designs tested per target, mostly at nanomolar affinity.

Computational design of soluble functional analogues of integral membrane proteins

This study designs soluble analogues of integral membrane proteins using deep learning, achieving high thermal stability and functional accuracy.