Author

Yasmeen N. Ruma

Howard Hughes Medical InstituteORCID 0000-0002-9817-8477Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Tamir GoneniD· 2 shared Alex J. VecchioiD· 1 shared Alexandria M. Mandriota· 1 shared Angus C. GreyiD· 1 shared Anna ShiriaevaiD· 1 shared Anthony A. KossiakoffiD· 1 shared Charles R. SandersiD· 1 shared Chinemerem P. OgbuiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiophysics

Tamir GonenORCID

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2 papers

Recent·Most cited

Biophysical Basis of Paracellular Barrier Modulation by a Pan-Claudin-Binding Molecule

Chinemerem P. Ogbu, Mason de las Alas, Alexandria M. Mandriota, Xiangdong Liu, Srajan Kapoor, Jagrity Choudhury, Yasmeen N. Ruma, Michael Goodman, Charles R. Sanders, Tamir Gonen, Anthony A. Kossiakoff, Michael E. Duffey, Alex J. Vecchio

The paper develops a synthetic antibody fragment that binds to 10 claudin subtypes, opening tight junctions and modulating paracellular permeability.

PNAS Nexus · Jun 1, 2025Peer-reviewedBiophysics

Structure of the lens MP20 mediated adhesive junction

William J. Nicolas, Anna Shiriaeva, Michael W. Martynowycz, Angus C. Grey, Yasmeen N. Ruma, Paul James Donaldson, Tamir Gonen

This study determines the structure of MP20, a lens membrane protein, revealing its tetrameric assembly and adhesive function in forming thin junctions essential for lens transparency.

Nature Communications · Mar 26, 2025Peer-reviewedBiophysics