Discovery of an APP-Selective BACE1 Inhibitor for Alzheimer's Disease
Jesus J. Campagna, Barbara M. Jagodzinska, Dongwook Wi, Chunni Zhu, Jessica L. Lee, Whitaker Cohn, Michael Jun, Chris Jean Elias, Samar Padder, Olivier Descamps, Clare A. Peters-Libeu, Qiang Zhang, Olivia F. Gorostiza, Karen S. Poksay, Patricia R. Spilman, , Varghese John
This paper identifies an APP-selective BACE1 inhibitor, FAH65, which shows substrate and enzyme selectivity, reduces Aβ levels, and improves cognitive performance in an AD mouse model.
Neurotherapeutics · May 20, 2025Peer-reviewedNeuroscience