Qiang Zhang

This study shows that inhibitory control during language comprehension and motor inhibition share a domain-general mechanism involving the subthalamic nucleus.

The paper identifies a delayed AQP4/SNTA1 expression imbalance linked to ion-homeostatic remodeling in chronic traumatic brain injury using temporally-resolved transcriptomic and proteomic data.

The paper describes an optimized nuclei isolation protocol for mouse brain tissues using benchtop centrifugation and magnetic enrichment to improve quality for snRNA-seq.

This study investigates how time estimation, movement, and reward anticipation contribute to prefrontal and striatal ramping activity in mice during interval timing tasks.

This study investigates how the fronto-subthalamic circuit implements selective response inhibition in humans using intracranial recordings and a novel task.

This paper identifies an APP-selective BACE1 inhibitor, FAH65, which shows substrate and enzyme selectivity, reduces Aβ levels, and improves cognitive performance in an AD mouse model.

This paper introduces Drop-BS, a droplet-based microfluidic method for single-cell bisulfite sequencing, enabling high-throughput DNA methylome profiling of up to 10,000 cells in 2 days.

This study examines interval timing deficits in P301S tau transgenic mice, finding they consistently underestimate temporal intervals compared to wild-type controls.

This study investigates whether cortical injection of alpha-synuclein preformed fibrils (PFF) affects interval timing in mice, finding no consistent deficits despite synucleinopathy.

The paper introduces native MOWChIP-seq, a low-input ChIP-seq method, and applies it to study protein binding differences between mouse brain regions.