Retrotransposon instability dominates the acquired mutation landscape of mouse induced pluripotent stem cells
Patricia Gerdes, Sue Mei Lim, Adam D. Ewing, Michael R. Larcombe, Dorothy Leung-Kwan Chan, Francisco Jose Sanchez-Luque, Lucinda Walker, Alexander L. Carleton, Cini James, Anja S. Knaupp, Patricia Eugenia Carreira, Christian Maximilian Nefzger, Ryan Lister, Sandra R. Richardson, Jose Maria Polo, Geoffrey J. Faulkner
The paper identifies retrotransposon insertions as the main source of mutations in mouse induced pluripotent stem cells, showing hypomethylation of LINE-1 elements and their impact on gene regulation.
Nature Communications · Dec 3, 2022Peer-reviewedGenomics