Patricia Eugenia Carreira

Innate immune sensing of cell traversal by Plasmodium sporozoites drives protective T cell responses

The paper shows that Plasmodium sporozoites trigger innate immune responses via cell traversal, which is essential for activating protective CD8+ T cells.

Conserved but mechanistically diverse piRNA defence against gypsy LTR retrotransposons in insect ovaries

The paper shows that piRNA pathways in insect ovaries defend against gypsy retrotransposons, with lineage-specific mechanisms across species.

B cells targeting parasites capture spatially linked antigens to secure T cell help

The paper investigates how B cells targeting Plasmodium parasites capture spatially linked antigens to receive T cell help, showing that B cells can obtain help from T cells specific to surface antigens, not just the same protein.

Retrotransposon instability dominates the acquired mutation landscape of mouse induced pluripotent stem cells

The paper identifies retrotransposon insertions as the main source of mutations in mouse induced pluripotent stem cells, showing hypomethylation of LINE-1 elements and their impact on gene regulation.