Stimulation-responsive enhancers regulate inflammatory gene activation through retention and modification of H2A.Z-variant accessible nucleosomes
Audrey Sporrij, Meera P. Prasad, Brejnev Muhizi Muhire, Eva Maria Fast, Margot E. Manning, Avik Choudhuri, Jodi D. Weiss, Michelle Koh, Song P. Yang, Robert E. Kingston, Michael Yevgeniy Tolstorukov, Hans C. Clevers, Leonard Ira Zon
The paper identifies how dmPGE2 regulates inflammatory gene activation in HSPCs by modulating enhancer chromatin structure through H2A.Z-variant nucleosome retention and acetylation.
bioRxiv · Sep 12, 2022 · PreprintDevelopmental Biology