Song P. Yang

Craters on the melanoma surface facilitate tumor-immune interactions and demonstrate pathologic response to checkpoint blockade in humans

The paper identifies crater-shaped structures in melanoma that enhance immune response to checkpoint blockade therapy in humans and zebrafish.

RNA methylation controls stress granule formation and function during erythropoiesis

This study shows that RNA methylation, specifically m6A, regulates stress granule formation and function during erythropoiesis by modulating ATXN2 expression and RNA translation.

BMP-dependent oligoclonal cancer attractor state precedes neural crest fate in melanoma initiation

The paper identifies a BMP-dependent attractor state in melanoma precursor cells that precedes neural crest fate and is associated with ID1 expression in human melanoma.

Leukemia-derived apelin selects endothelial niche clones to promote tumorigenesis

The paper shows that leukemia cells secrete apelin, which promotes clonal expansion of niche endothelial cells and drives leukemogenesis in zebrafish.

A molecular switch: Ro5-3335 drives hematopoietic stem cell division and clonality through distinct RUNX1 binding partners

This study identifies Ro5-3335 as a chemical that increases HSC clone number and clonal diversity by altering RUNX1 binding partners in zebrafish and mouse models.

Transcription factor induction of vascular blood stem cell niches in vivo

This study identifies transcription factors that induce vascular blood stem cell niches in vivo, enabling synthetic niche generation and potential therapeutic applications.

Stimulation-responsive enhancers regulate inflammatory gene activation through retention and modification of H2A.Z-variant accessible nucleosomes

The paper identifies how dmPGE2 regulates inflammatory gene activation in HSPCs by modulating enhancer chromatin structure through H2A.Z-variant nucleosome retention and acetylation.

Niche signals regulate continuous transcriptional states in hematopoietic stem cells

The paper identifies six HSC states and shows niche perturbations induce rapid transitions between them, revealing HSC-specific molecular signatures and chromatin features related to regenerative potential.

Specific Oxylipins Enhance Vertebrate Hematopoiesis via the Receptor GPR132

The paper identifies GPR132 as a specific receptor for certain oxylipins that enhance hematopoiesis in vertebrates, using bioinformatics and functional assays.